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KMID : 1123920080220051192
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 5 p.1192 ~ p.1195
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Acute Toxicity Study on Sipjeondaebo-tang in Rats
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Ma Jin-Yeul
Hwang Dae-Sun
Lee Nam-Hun
Ha Hye-Kyung
Yu Young-Beob
Shin Hyun-Kyu
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Abstract
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Sipjeondaebo-tang has been traditionally prescribed a medicine as a restorative. In this study, we investigated the acute toxicity about water-extracted Sipjeondaebo-tang. Thirty rats completed 14 days of oral Sipjeondaebo-tang at the respective doses of 0(control group), 2000 and 5000 mg/kg. We observed survival rates, general toxicity, change of body weight and autopsy. To be confirmed the data for the toxicity and safety problems of oriental medicine prescription. Compared with the control group, we could not find any toxic alteration in all treated groups (2000 and 5000 mg/kg). LD50 of Sipjeondaebo-tang was over 5000 mg/kg and it is very safe to SD rats.
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KEYWORD
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Sipjeondaebo-tang, Acute toxicity, LD50, Safety
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